6-Phosphogluconic Dehydrogenase Antibodies

Target Information

6-Phosphogluconic acid, also known as 6-phospho-D-gluconate or gluconate 6-phosphate, belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit. 6-Phosphogluconic acid is soluble (in water) and a moderately acidic compound (based on its pKa). 6-Phosphogluconic acid has been found in human adipose tissue, epidermis and prostate tissues, and has also been detected in multiple biofluids, such as saliva and blood. Within the cell, 6-phosphogluconic acid is primarily located in the endoplasmic reticulum. 6-Phosphogluconic acid exists in all eukaryotes, ranging from yeast to humans. 6-Phosphogluconic acid participates in a number of enzymatic reactions. In particular, 6-Phosphogluconic acid can be biosynthesized from gluconolactone and water through the action of the enzyme 6-phosphogluconolactonase. In addition, 6-Phosphogluconic acid can be converted into D-ribulose 5-phosphate; which is catalyzed by the enzyme putative uncharacterized protein PGD. In humans, 6-phosphogluconic acid is involved in the pentose phosphate pathway. 6-Phosphogluconic acid is also involved in several metabolic disorders, some of which include glucose-6-phosphate dehydrogenase deficiency, ribose-5-phosphate isomerase deficiency, transaldolase deficiency, and cancer (via the Warburg effect). Outside of the human body, 6-phosphogluconic acid can be found in a number of food items such as white lupine, american pokeweed, peach, and star anise. This makes 6-phosphogluconic acid a potential biomarker for the consumption of these food products.